Year 9 Science · Unit 1 · Lesson 4

First Line of Defence

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Learning Goals

Order the steps

Number the events from 1 to 6 to show the correct order. Event 1 = what happens first when a pathogen is breathed in through the nose.

OrderEvent
Cilia in the respiratory tract beat in coordinated waves, sweeping the mucus and trapped pathogen upward toward the throat.
The pathogen is swallowed and reaches the stomach.
The pathogen-laden mucus arrives in the stomach, where hydrochloric acid (pH 2) destroys most pathogens.
The pathogen enters the nose and is filtered by nasal hairs, slowing its travel.
The pathogen becomes stuck in the sticky mucus secreted by the mucous membranes lining the respiratory tract.
The pathogen cannot penetrate intact mucous membranes and would need to be swallowed to continue into the body.

Compare two

Complete the table to compare skin (physical barrier) and stomach acid (chemical barrier).

FeatureSkin (physical barrier)Stomach acid (chemical barrier)
Mechanism, how does it stop pathogens?
Where in the body does it act?
Types of pathogen it stops
How can this barrier be bypassed?
One specific chemical or structural feature that makes it effective

1. Smokers have damaged cilia in their respiratory tracts. Using your knowledge of the mucociliary escalator, explain why smokers are more likely to develop lung infections than non-smokers.

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2. Lactoferrin in breast milk is a chemical barrier that binds iron, making it unavailable to bacteria. Explain why removing the iron supply would help stop a bacterial infection.

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Wrap Up

In one sentence, what was the main idea of this lesson?